TP53.org is a site dedicated to bringing basic, advanced and current information on the TP53 gene, p53 protein and there significance. The TP53 gene has revolutionized our understanding of the molecular biology of cancer, cancer initiation and cancer progression. The TP53 gene is altered in more than half of all cancers, and its dysfunction is associated with more aggressive cancers and a worse prognosis. Numerous research teams around the world are pursuing advancing in our knowledge base on the TP53 gene and the p53 protein and changes in these entities. It is of prime importance to have an understanding of the TP53 gene and p53 protein in order to be able to understanding anything about the molecular biology of cancer.
p53 is the most referenced and well-know tumor suppressor. It was discovered by Arnold Levine, David Lane and Llyod Old in the late 70's. Initially thought to be an oncogene, p53 was later found to be responsive to ultraviolet induced DNA damage within cells. This study was done by Warren Maltzman. Subseqeuntly, Michael Kastan revealed that p53 was involved in DNA damage reponse through signal transduction pathways. Currently, there is intense research int he field of p53 and finding other proteins with similar functions and structure.
Other names p53 is known by: p53, p53 protein, tumor antigen p53, tumor suppressor p53, antigen NY-CO-13, phosphoprotein p53, and TRP53 (transformation-related protein 53).